Information for other Bipolar Researchers

Bibliography of Research by the NIMH Bipolar Genetics Collaborative

Badner JA, Gershon ES, Goldin LR. Optimal ascertainment strategies to detect linkage to common disease alleles. Am J Hum Genet 63(3):880-888, 1998.

Badner JA, Gershon ES. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Molec Psychiat 7:405-11, 2002.

Beirut L, Reich T. Imputing diagnoses for genetic epidemiologic studies without face-to-face interviews. Int Rev Psychiat 4:287-293, 1994.

Berrettini WH. Progress and pitfalls: Bipolar molecular linkage studies. J Affect Disord 50:287-97, 1998.

Berrettini WH. Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. Biol Psychiat 47:245-251, 2000.

Berrettini WH. Are schizophrenic and bipolar disorders related: Review of family and molecular studies. Biol Psychiat 48:531-38, 2000.

Berrettini WH: Molecular linkage studies of bipolar disorders. Bipolar Disorders 3: 276-283, 2001.

Berrettini WH: Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. Biol Psychiat 47: 245-251, 2000.

Blehar MC, Faraone SV, Zeller PJ, Nurnberger Jr JI, Tsuang MT, Kirch D, Shore D, Gershefski JMA, Reich T, Cloninger CR, Rau NL, DePaulo JR, Kaufmann, CA, Weise RE. Differentiation of schizoaffective bipolar disorder from bipolar disorder and schizophrenia. Depression 3:309-315, 1996.

Blehar MC, DePaulo Jr., Gershon ES, Reich T, Simpson SG, Nurnberger Jr JI. Women with bipolar disorder: findings from the NIMH genetics initiative sample. Psychopharmacol Bull 34(3):239-243, 1998.

Breschel TS, McInnis MG, Margolis RL, Sirugo G, Corneliussen B, Simpson SG, McMahon FJ, MacKinnon DF, Xu JF, Pleasant N, Huo Y, Ashworth RG, Grundstrom T, Kidd KK, DePaulo JR Jr., Ross CA. A novel, heritable expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1. Hum Molec Genet 11:1155-1163, 1997.

Chen H, Huo Y, Patel S, Zhu X, Swift-Scanlan T, Reeves RH, DePaulo R Jr., Ross CA, MiInnis MG. Gene identification using exon amplification on human chromosome 18q21: Implications for bipolar disorder. Molec Psychiat 5:502-509, 2000.

Chen H, Ross CA, Wang N, Huo Y, MacKinnon DF, Potash JB, Simpson SG, McMahon FJ, DePaulo JR Jr., McInnis MG. NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene. Eur J Hum Genet 9:922-930, 2001.

Cichon S, Schumacher J, Muller DJ, Hurter M, Windemuth C, Strauch K, Hemmer S, Schulze TG, Schmidt-Wolf G, Albus M, Borrmann-Hassenbach M, Franzek E, Lanczik M, Fritze J, Kreiner R, Reuner U, Weigelt B, Minges J, Lichtermann D, Lerer B, Kanyas K, Baur MP, Wienker TF, Maier W, Rietschel M, Propping P, Nothen MM. A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Molec Genet 10(25):2933-2944, 2001.

Craddock N, Khodel V, Van Eerdewegh P, Reich T. Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Genet 57:690-702, 1995.

Culverhouse R, Suarez BK, Lin J, Reich T. A perspective on epistatis: Limits of models displaying no main effect. Am J Hum Genet 70:461-471, 2002.

DeLisi LE, Craddock NJ, Detera-Wadleigh S, Foroud T, Gejman P, Kennedy JL, Lendon C, Macciardi F, McKeon P, Mynett-Johnson L, Nurnberger Jr JI, Paterson A, Schwab S, Van Broeckhoven C, Wildenauer D, Crow TJ. Update on chromosomal locations for Psychiatric disorders: Report of the Interim Meeting of Chromosome Workshop Chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey , California , October 14-18, 1999 . Am J Med Genet (Neuropsychiat Genet ) 96:434-449, 2000.

DePaulo JR, Phillips AE, Potash JB, McInnis MG and McMahon FJ. The current status and prospects for genetic studies of bipolar disorder. Clin Neurosci Res 1:153-15, 2001.

Detera-Wadleigh SD, Badner JA, Goldin LR, Berrettini W, Sanders AR, Rollins DY, Turner G, Moses T, Haerian H, Muniec D, Nurnberger Jr JI, Gershon ES. Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder on 21q. Am J Hum Genet 58:1279-1285, 1996.

Detera-Wadleigh SD, Badner JA, Yoshikawa T, Sanders AR, Goldin LR, Turner G, Rollins DY, Moses T, Guroff JJ, Kazuba D, Maxwell ME, Edenberg HJ, Foroud T, Lahiri D, Nurnberger Jr JI, Stine OC, McMahon F, Meyers DA, MacKinnon D, Simpson S, McInnis M, DePaulo JR, Rice J, Goate A, Reich T, Blehar MC, Gershon ES. Initial Genome Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q. Am J Med Genet (Neuropsychiat Genet ) 74:254-262, 1997.

Detera-Wadleigh SD, Badner J A, Berrettini WH, Yoshikawa T, Goldin LR, Turner G, Rollins DY, Moses T, Sanders AR, Karkera JD, Esterling LE, Zeng J, Ferraro TN, Guroff JJ, Kazuba D, Maxwell ME, Nurnberger Jr JI. Gershon, E.S. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q and 18p11.2. PNAS 96:5604-5609, 1999.

Dick DM, Foroud T, Edenberg HJ, Miller M, Bowman E, Rau NL, DePaulo JR, McInnis M, Gershon E, McMahon F, Rice JP, Bierut LJ, Reich T, Nurnberger Jr JI. Apparent replication of suggestive linkage on Chromosome 16 in the NIMH Genetics Initiative bipolar pedigrees. Am J Med Genet (Neuropsychiat Genet) 114:407-412, 2002.

Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Hahn R, Widmark C, McKinney E, Sutton L, Ballas C, Grice D, Berrettini W, Byerley W, Coryell W, DePaulo R, MacKinnon DF, Gershon ES, Kelsoe JR, McMahon FJ, McInnis M, Murphy DL, Reich T, Scheftner W, Nurnberger Jr JI. Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the national institute of mental health genetics initiative. Am J Hum Genet 73:107-114, 2003.

Dorr DA, Rice JP, Armstrong C, Reich T, Blehar M. A meta-analysis of chromosome 18 linkage data for bipolar disorder. Genet Epidemiol 14:617-622, 1997.

Drevets WC, Price JL, Simpson JR, Todd R, Reich T, Vaneer M, Raichle ME. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386:824-827, 1997.

Drevets WC, Price JL, Bardgett ME, Reich T, Todd R, Raichle MC. Glucose metabolism in the amygdala in depression: Relationship to diagnostic subtype and stressed plasma cortisol levels. Phamacol Biochem Behav 71:431-447, 2002.

Edenberg HJ, Foroud T, Conneally PM, Sorbel JJ, Carr K , Crose C, Willig C, Zhao J, Miller M, Bowman E, Mayeda A, Rau NL, Smiley C, Rice JP, Goate A, Reich T, Stine OC, McMahon F, DePaulo JR, Meyers D, Detera-Wadleigh SD, Goldin LR, Gershon ES, Blehar MC, Nurnberger Jr JI. Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. Am J Med Genet (Neuropsychiat Genet ) 74:238-246, 1997.

Esterling LE, Matise, TC, Sanders AR, Yoshikawa T, Overhauser J, Gershon ES, Moskowitz MT , Detera-Wadleigh SD. An integrated physical map of 18p11.2: a susceptibility region for bipolar disorder. Molec Psychiat 2:501-504, 1997.

Esterling LE, Detera-Wadleigh SD, Berrettini WH, Gershon ES, Bengel D, Badner JA, Turner G, Yoshikawa T. Serotonin transporter (5-HTT) gene and bipolar affective disorder. Am J Med Genet (Neuropsychiat Genet) 81(1):37-40, 1998.

Faraone SV, Blehar M, Pepple J, Moldin SO, Norton J, Nurnberger Jr JI, Malaspina D, Kaufmann CA, Reich T, Cloninger CR, DePaulo, JR, Berg K, Gershon ES, Kirch DG and Tsuang MT. Diagnostic accuracy and confusability analyses: An application to the Diagnostic Interview for Genetic Studies. Psychol Med 26:401-410, 1996.

Foroud T, Castelluccio PF, Koller DL, Edenberg HJ, Miller M, Bowman E, Rau NL, Smiley C, Rice JP, Goate A, Armstrong C, Bierut LJ, Reich T, Detera-Wadleigh SD, Goldin LR, Badner JA, Guroff JJ, Gershon ES, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MC, Nurnberger Jr JI. Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees. Am J Med Genet (Neuropsychiat Genet) 96:18-23, 2000.

Gerhard DS, LaBuda MC, Marshall D, Otten K, Reich T, Todd RD. A linkage map of chromosome 6 based on 2 large kindreds segregating bipolar affective disorder. DNA Sequence 8(3):143-146, 1997.

Gershon E, Nurnberger Jr JI. Bipolar Illness. In: JM Oldham, MR Riba (Eds) Review of Psychiatry , American Psychiatric Press, Inc., Washington, D.C. 14:405-424, 1995.

Gershon ES, Badner JA, Detera-Wadleigh SD, Ferraro TN, Berrettini WH. Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees. Am J Med Genet (Neuropsychiat Genet ) 67:202-207, 1996.

Gershon ES, Badner JA, Goldin LR, Sanders AR, Cravchik A, Detra-Wadleigh SD. Closing in on genes for manic-depressive illness and schizophrenia. Neuropsychopharmacol 18(4):233-242, 1998.

Gershon ES. Making progress: Does clinical research lead to breakthroughs in basic biomedical sciences? Perspec Biol Med 43(1):95-102, 1998.

Gershon ES. Bipolar illness and schizophrenia as oligogenic diseases: implications for the future. Biol Psychiat 47:240-244, 2000.

Gershon ES, Badner JA. Incorporation of molecular data and redefinition of phenotype: new approaches to genetic epidemiology of bipolar manic-depressive illness (BP) and schizophrenia (SZ). Dialogues in Clinical Neurosci 3:63-71, 2001.

Ghosh S, Reich T. Integrating sibship data for mapping quantitative loci. Am J Hum Genet, 66:169-182, 2002.

Goldin LR, Kelsoe J, Smyth C, Curtis D, Gurling H, Endicott J, Gilliam C, Knowles J, Baron M, Rietschel M, Maier W, Kreiner R, Franzek E, Albus M, Baur M, Fimmers R, Cichon S, Propping P, Nothen M, Meyers D, McMahon F, DePaulo R, Stine OC, Berrettini WH, Gershon ES. Description of the genetic analysis workshop on bipolar disorder linkage data sets. Genet Epidemiol 14(6):563-569, 1998.

Greenberg BD, McMahon FJ, Murphy DL: Serotonin transporter candidate gene studies in affective disorders and personality: promises and potential pitfalls. Molec Psychiat 3:186-189, 1998.

Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Kelsoe JR. Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. Am J Med Genet (Neurophsychiat Genet) 105:145-151, 2001.

Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Shaw SH, Kelsoe JR. Segmental linkage disequilibrium within the dopamine transporter gene. Molec Psychiat 7:165-173, 2002.

Gu C, Miller MB, Reich T, Rao DC. The affected pedigree-member method revisited under population stratification. In: EM Holloran, S Geisser (Eds) Statistical Methods in Genetics: The IMA Vol. in Mathematics and its Applications. New York : Springer-Verlag Vol. 112:165-180, 1999.

Gu C, Suarez BK, Reich T, Todorov AA. A chromosome-based method to infer IBD scores for missing and ambiguous markers. Genet Epidemiol 12:871-876, 1995.

Hinrichs A, Lin JH, Reich T, Bierut L, Suarez G. Markov chain Monte Carlo linkage analysis of a complex qualitative phenotype. Genet Epidemiol 17(S1):S615-S620, 1999.

Hinrichs A, Reich T. Markov Chain Monte Carlo linkage analysis of complex quantitative phenotypes. Genet Epidemiol 21(S1):S662-S667, 2001.

Jamison KR, McInnis MG. Genetic studies of manic-depressive illness. Nature Med 2:521-522, 1996.

Kelsoe JR, Sadovnick AD, Kristbjarnarson H, Bergesch P, Mroczkowski-Parder Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet (Neuropsychiat Genet) 67:533-540, 1996.

Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert H. Genome survey indicates a susceptibility locus for bipolar disorder on chromosome 22. PNAS 98:585-590, 2001.

Kornberg JR, Brown JL, Sadovnick AD, Remick RA, Keck JR PE, McElroy SL, Rapaport MH, Thompson P, Kaul JB, Vrabel CM, Schommer SC, Wilson T, Pizzuco D, Jameson S, Schibuk L, Kelsoe JR. Evaluating the parent-of-origin effect in bipolar affective disorder. J Affect Disord 59(3):183-192, 2000.

Lachman HM, Kelsoe JR, Remick RA, Sadovnick AD, Rapaport MH, Lin M, Pazur BA, Roe AA, Saito T, Papolos DR. Linkage studies suggest a possible locus for bipolar disorder in the velo-cardio-facial syndrome region on chromosome 22. Am J Med Genet (Neuropsychiat Genet) 74:121-128. 1997.

Liang SG, Sadovnick AD, Remick RA, Keck PE , McElroy SL, Kelsoe JR. Linkage disequilibrium study of bipolar disorder and microsatellite markers on 22q13. Psychiat Genet , in press.

Lin JH, Hinrichs A, Liu K-Y, Bierut L, Suarez BK. Genetic dissection of a complex trait. Genet Epidemiol 17(S1): S633-S638, 1999.

Liu C, Badner JA, Christian SL, Guroff JJ, Detera-Wadleigh SD , Gershon ES. Fine mapping supports previous linkage evidence for a bipolar disorder susceptibility locus on 13q32. Am J Med Genet (Neuropsychiat Genet) 105:375-380, 2001.

McInnis MG, McMahon FJ, Chase GA, Simpson SG, Ross CA, DePaulo JR. Anticipation in bipolar affective disorder. Am J Hum Genet 53:385-390, 1993.

McInnis MG. Anticipation – An old idea in new genes. Am J Hum Genet 59(5):973-979, 1996.

McInnis MG. Recent advances in the genetics of bipolar disorder. Psychiat Annals 27(7):482-488, 1997.

McInnis MG, Margolis RL. Anticipation, triplet repeats and psychiatric disorders. In: Analysis of triplet repeat disorders . DC Rubensztein, MR Hayden (eds.) Oxford , Bios Scientific Publishers. Pp. 239-256, 1998.

McInnis MG. Genetic anticipation and brain genes. In: Genetics and psychiatric Disorders. J Wahlstrom (ed.), Oxford, Elsevier Science Ltd. Pp. 219-234, 1998.

McInnis MG, Margolis RL. Anticipation and psychiatric disorders. In: Genetic instabilities and heriditary neurological diseases. RG Wells, ST Warren (eds.) San Diego, Academic Press Inc. Pp. 428-444, 1998.

McInnis MG. The assent of a nation; Genethics and Iceland . Clinical Genetics 55:234-239, 1999.

McInnis MG, Breschel TS, Margolis RL, Chellis J, MacKinnon DR, McMahon FJ, Simpson SG, Lan T-H, Chen H, Ross CA, DePaulo JR. Family-based association analysis of the hSKCa3 potassium channel gene in bipolar disorder. Molec Psychiat 4:217-219, 1999.

McInnis MG, Dick DM, Willour VL, Avramopoulos D, MacKinnon DF, Simpson SG, Potash JB, Edenberg HJ, Bowman ES, McMahon FJ, Smiley C, Chellis JL, Huo Y, Diggs T, Meyer ET, Miller M, Matteini AT, Rau NL, DePaulo JR, Gershon ES, Badner JA, Rice JP, Goate AM, Detera- Wadleigh SD, Nurnberger Jr JI, Reich T, Zandi PP, Foroud TM. Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the national institute of mental health genetics initiative bipolar pedigrees. Society of Bio Psychiat 54:1265-1273, 2003.

McInnis MG, Swift-Scanlan T, Mahoney AT, Vincent J, Verheyen G, Lan TH, Oruc L, Riess O, van Broeckhoven C, Chen H, Kennedy JL, MacKinnon DF, Margolis RL, Simpson SG, McMahon FJ, Gershon ES, Reich T, DePaulo JR, Ross CA. Allelic distribution of CTG18.1 in Caucasian populations: association studies in bipolar disorder, schizophrenia, and ataxia. Molec Psychiat 5:439-442, 2000.

McMahon FJ, Chen YS, Patel S, Kokoszka J, Brown MD, Torroni A, DePaulo JR, Wallace DC. Mitochondrial DNA sequence diversity in bipolar affective disorder. Am J Psychiat 157:1058-1064, 2000.

McMahon FJ, Simpson SG, McInnis MG, Badner JA, MacKinnon DR, DePaulo JR. Linkage of bipolar disorder to chromosome 18q and the validity of bipolar II disorder. Arch Gen Psychiat 58(11):1025-1031, 2001.

McMahon FJ, DePaulo J.R. Affective Disorders. In: JL Jameson (Ed) Principles of Molecular Medicine Totowa , NJ Humana,1998.

McMahon FJ, Stine OC, Meyers DA, Simpson SG, DePaulo JR. Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet 56:1277-1286, 1995.

McMahon FJ, Hopkins PJ, Xu J, McInnis MG, Shaw S, Cardon L, Simpson SG, MacKinnon DF, Stine OC, Sherrington R, Meyers DA, DePaulo JR. Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series. Am J Hum Genet 61:1397-1404, 1997.

McMahon FJ, Thomas CJM, Koskela RJ, Breschel TS, Hightower TC, Rohrer N, Savino C, McInnis MG, Simpson SG, DePaulo JR. Integrating clinical and laboratory data in genetic studies of complex phenotypes: a network-based data management system. Am J Med Genet (Neuropsychiat Genet) 81:248-256, 1998.

McMahon FJ. Genetics of mood disorders. In: Grossberg GT et al (Eds) Comprehensive Review of Geriatric Psychiatry 3rd ed. Baltimore Williams & Wilkins, in press.

Malaspina D, Goetz RR, Harkavy Friedman J, Kaufmann CA, Faraone SV, Tsuang M, Cloninger RC, Nurnberger Jr JI, Blehar MC. Traumatic brain injury and schizophrenia in members of schizophrenia and bipolar disorder pedigrees. Am J Psychiat 158:3, 2001.

MacKinnon DF, Zandi PP, Cooper J, Potash JB, Simpson SG, Gershon E, Nurnberger Jr JI, Reich T, DePaulo JR. Familial bipolar and panic disorder in the NIMH genetics initiative bipolar disorder study. Am J Psychiat , in press.

MacKinnon DF, Zandi PP, Gershon E, Nurnberger Jr JI, Reich T, DePaulo RJ. Rapid switching of mood in families with multiple cases of bipolar disorder. Arch Gen Psychiat 60:921-928, 2003.

MacKinnon DF, Zandi PP, Gershon ES, Nurnberger Jr JI, DePaulo RJ. Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder. Am J Psychiat 160:1696-1698, 2003.

Moldin SO and Reich T. The genetic analysis of depression: Future directions. Clin Neurosci 1:139-145, 1993.

NIMH Genetics Initiative Bipolar Group: Nurnberger Jr JI, DePaulo JR, Gershon ES, Reich T, Blehar MC, Edenberg H, Foroud T, Miller M, Bowman, ES , Mayeda A, Rau NL, Smiley C, Conneally PM, McMahon PM, Meyers D, Simpson S, McInnis M, Stine OC, Detera-Wadleigh S, Goldin L, Guroff JJ, Maxwell E, Kazuba D, Gejman PV, Badner J, Sanders A, Rice J, Bierut L, Goate A. Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees. A preliminary report. Am. J Med Genet (Neuropsychiat Genet ) 74:227-237, 1997.

Neuman RJ, Bierut L, Rasmussen E, Saccone NL, Rice JP, Corbett J, Sun L, L K-Y. A clustering approach for localizing disease susceptibility loci. Genet Epidemiol, 21 Suppl 1:S534-9, 2001.

Neuman RJ, Saccone NL, Holmans P, Rice JP, Sun L. Clustering methods applied to allele sharing data. Genet Epidemiol 19(Suppl 1):S57-S63, 2000.

Niculescu AB , Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol Genom 4:83-91, 2000.

Nurnberger Jr JI, Berrettini WH. Psychiatric Genetics . Chapman & Hall, London , 1998.

Nurnberger Jr, JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T, Miller M, Bowman ES, DePaulo JR, Cloninger CR, Robinson G, Moldin S, Gershon ES, Maxwell E, Guroff JJ, Kirch D, Wynne D, Berg K, Tsuang MT, Faraone SV, Pepple JR. Diagnostic interview for genetic studies (DIGS). Arch Gen Psychiat 51: 849-859, 1994.

Nurnberger Jr JI, Foroud T. Chromosome 6 Workshop Report (Santa Fe, NM, October 1997). Psychiat Genet 8:79-84, 1998.

Nurnberger Jr JI, Berrettini W. Psychiatric Genetics. In: MH Ebert, PT Loosen, B Nurcombe (Eds). Current Diagnosis & Treatment in Psychiatry , Lange Medical Books/McGraw Hill, New York , pp 61-71, 2000.

Nurnberger Jr JI, Foroud T. Genetics of bipolar affective disorders. Curr Psychiatry Rep 2(2):148-157, 2000.

Nurnberger Jr JI, Foroud T, Flury L, Su J, Meyer ET, Hu K, Crowe R, Edenberg H, Goate A, Bierut L, Reich T, Schuckit M, Reich W. Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am J Psychiat 158(5):718-724, 2001.

Overhauser J, Berrettini WH, Rojas K. Affective disorder associated with a balanced translocation involving chromosomes 14 and 18. Psychiat Genet 8:53-56, 1998.

Petronis A, Gottesman II, Crow TJ, Delisi LE, Klar AJ, Macciardi F, McInnis MG, McMahon FJ, Paterson AD, Skuse D, Sutherland GR. Psychiatric epigenetics : a new focus for the new century. Molec Psychiat 5:342-346, 2000.

Potash, JB and DePaulo, JR. Searching high and low: A Review of the genetics of bipolar disorder. Bipolar Disorders . 2: 8-26, 2000.

Potash JB, Kane HS, Chiu Y, Simpson SG, MacKinnon DF, McInnis MG, McMahon FJ, DePaulo JR. Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships. Am J Psychiat 157:2048-2050, 2000.

Potash, JB, Willour VL, Chiu Y-F, Simpson SG, MacKinnon DF, Pearlson GD, DePaulo

JR, and McInnis MG. The familial aggregation of psychotic symptoms in bipolar disorder. Am J Psychiat 158:1258-64, 2001.

Prathikanti S, McMahon FJ. Genome scans for susceptibility genes in bipolar affective disorder. Ann Med 33:257-62, 2001.

Reich T. Genetic linkage studies of bipolar disorder. In: Curr Opin in Psychiat J. Theobald (Ed). Ch. 8:3-6, 1995.

Rice JP. The role of meta-analysis in linkage studies of complex traits. Am J Med Genet (Neuropsychiat Genet) 74:112-114, 1997.

Rice J. Genetic analysis of bipolar disorder: summary of GAW10. Genet Epidemiol 14:549-561, 1997.

Rice J. Diagnosis as a covariate in sib-pair linkage analysis. Am J Med Genet (Neuropsychiat Genet) 105:55-56, 2001.

Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shantia S, Gopalakrishnan G, Edenberg HJ, Foroud T, Nurnberger Jr JI, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MC, and Reich T. Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12. Am J Med Genet (Neuropsychiat Genet) 74:247-253, 1997.

Rice JP, Rochberg N, Neuman RJ, Saccone NL, Yu Liu K, Zhang X. Culverhouse Rl. Covariates in linkage analysis. Genet Epidemiol 17:S691-S695, 1999.

Rice JP, Saccone NL, Corbett J. The LOD score method. In: DC Rao (Ed) Acad Press 42:99-113, 2001.

Rice JP, Saccone NL, Rasmussen E. Definition of a phenotype. In: DC Rao (Ed) Acad Press 42:69-76, 2001.

Rice JP, Saccone NL, Suarez BK. The design of studies for investigating linkage and association. In: T Bishop, P Sham (Eds) Analysis of Multifactorial Diseases pp 37-62 ,2000.

Rojas K, Liang L, Hohnson EI, Berrettini WH, Overhauser J. Identification of candidate genes for affective disorder on 18p11. Molec Psychiat 5:389-95, 2000.

Saccone NL, Rice JP, Downey JR JI, Meyer DJ, Neuman RJ, Rice JP. Mapping genotype to phenotype for linkage analysis. Genet Epidemiol 17:S703-S708, 1999.

Schulze TG, Chen YS, Akula N, Hennessy K, Badner JA, McInnis MG, DePaulo JR Jr., Schumacher J, Cichon S, Propping P, Maier W, Reitschel M, Nothen MM, McMahon FJ. Can long-range microsatellite data be used to predict short-range linkage disequilibrium? Hum Mol Genet 11:1363-1372, 2002 .

Schulze TG, Buervenich S, Badner JA, Steele CJM, Detera-Wadleigh SD, Dick D, Foroud T, Cox NJ, MacKinnon DF, Potash JB, Berrettini WH, Byerley W, Coryell W, DePaulo JR, Gershon ES, Kelsoe JR, McInnis MG, Murphy DL, Reich T, Scheftner W, Nurnberger Jr JI, McMahon FJ, Straub etal. Loci on chromosome 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees . Biol Psychiat 56:218-23, 2004.

Schulze TG and McMahon FJ: Genetic association mapping at the crossroads: Which test and why? Am J Med Genet (Neuropsychiat Genet) , 114(1):1-11, 2002.

Sequardo R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger Jr JI, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo S, Berrettini WH, Yoshikawa T, Peltonen L, Lonnqvist J, Nothen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Boluin J, Antonarakis ST, Akarsu N. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am J. Hum Genet 73:49-62, 2003.

Sherman SL, DeFries JC, Gottesman II, Loehlin JC, Meyer JM, Pelia MZ, Rice J, Waldman I. Recent developments in human behavioral genetics: past accomplishments and future directions. Am J Hum Genet 60:1265-1275, 1997.

Simpson SG, McMahon FJ, McInnis MG, MacKinnon DF, Edwin D, Folstein SE, DePaulo JR Jr. Diagnostic reliability of Bipolar II Disorder. Arch Gen Psychiat 2002.

Stassen HH, Ragaz M and Reich T. Age-of-onset or age-cohort changes in the lifetime occurrence of depression? Psychiat Genet 7:27-34, 1997.

Stine OC, McMahon FJ, Li-shiun C, Jianfeng XU, Meyers DA, MacKinnon DF, Simpson S, McInnis MG, Rice JP, Goate A, Reich T, Edenberg HJ, Foroud T, Nurnberger Jr JI, Detera-Wadleigh SD, Goldin LR, Guroff J, Gershon ES, Blehar MC, and DePaulo JR. Initial genome screen for bipolar disorder in the NIMH Genetics Initiative pedigrees: chromosomes 2, 11, 13, 14 and X. Am J Med Genet (Neuropsychiat Genet) 74:263-269, 1997.

Suarez BK, Hampe CL, O'Rourke D, Van Eerdewegh P, Reich T. Sib-based detection of QTLs. Genet Epidemiol 12:675-680, 1995.

Taillon-Miller P, Bauer-Sardina I, Saccone NL, Puetzel J, Laitinen T, Cao A, Kere J, Pilia G, Rice JP, Kwok PY. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nat Genet 25:324-328, 2000.

Todd RD, Reich W, Reich T. Prevalence of affective disorder in the child and adolescent offspring of a single kindred: A pilot study. J Am Acad Child Adol Psych 33:198-207, 1994.

Todd RD, Reich W, Joshi P, DePaulo JR, Nurnberger Jr JI, Reich T. Psychiatric diagnoses in the child adolescent members of extended families identified throughout adult bipolar affective disorder probands. J Am Acad Adol Psych 35: 664-671, 1996.

Vuoristo JT, Berrettini WH, Overhauser J, Prockop DW, Ferraro TN, Ala-Kokko L. Sequence and genomic organization of the human G-protein Golf[alpha] gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia. Molec Psychiat 5:495-501, 2000.

Vuoristo J, Berrettini WH, Ala-Kokko L. C18orf2, a novel, highly conserved intronless gene within intron 5 of the GNAL gene on chromosome 18p11. Cytogenet Cell Genet 93:19-22, 2001.

Williams J, Farmer AE, Ackenheil M, Kaufmann CA , McGuffin P, and the OPCRIT Reliability Research Group: A Multicentre inter-rater reliability study using the OPCRIT computerized diagnostic system. Psychol Med 26:775-783, 1996.

Willour VL, Zandi PP, Huo Y, Diggs TL, Chellis JL, MacKinnon DF, Simpson SG, McMahon FJ, Potash JB, Gershon ES, Reich T, Foroud T, Nurnberger Jr JI, DePaulo JR, McInnis MG. Amer J Med Genet Part B (Neuropsychia Genet) 121B:21-27, 2003.

Zandi PP, Willour VL, Huo Y, Chellis J, Potash JB, MacKinnon DF< Simpson SG, McMahon FJ, Gershon E, Reich T, Foroud T, Nurnberger Jr JI, DePaulo JR, McInnis MG. Amer J Med Genet Part B (Neuropsychia Genet) 119B:69-76, 2003.

Over 70 presentations have also been made at national and international meetings.

 

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